Obesity is a global pandemic associated with macro-and microvascular endothelial
dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk …

The detrimental impact of obesity on human health is increasingly evident with the rise in
obesity-related diseases. Skeletal muscle, the crucial organ responsible for energy balance …

Obesity is associated with a chronic state of low-grade inflammation and progressive tissue
infiltration by immune cells and increased expression of inflammatory cytokines. It is …

Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin
signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by …

Background Quercetin (QUE) is a flavonol reported with anti-inflammatory and antioxidant
activities, and previous results from the group of this study have demonstrated its …

In humans, obesity is associated with brain inflammation, glial reactivity, and immune cells
infiltration. Studies in rodents have shown that glial reactivity occurs within 24 hr of high‐fat …

Consumption of saturated fat-enriched diets during adolescence has been closely
associated with the reduction of hippocampal synaptic plasticity and the impairment of …

Traumatic brain injury (TBI) is a major health problem with high rates of mortality and
morbidity worldwide. The response of the brain to TBI is orchestrated by a number of …

Background: Interleukin-6 (IL-6) is a pleiotropic and multifunctional cytokine that plays a
critical role in induction of experimental autoimmune encephalomyelitis (EAE), a mouse …

Glial cells can mediate hypothalamic inflammatory processes induced in response to a high-
fat diet (HFD). We used magnetic-activated cell sorting (MACS) to isolate microglia and …