[HTML][HTML] Promising bioactive compounds from the marine environment and their potential effects on various diseases

A Karthikeyan, A Joseph, BG Nair - Journal of Genetic Engineering and …, 2022 - Elsevier
Background The marine environment hosts a wide variety of species that have evolved to
live in harsh and challenging conditions. Marine organisms are the focus of interest due to …

An update on the anticancer activity of xanthone derivatives: A review

YS Kurniawan, KTA Priyangga, Jumina, HD Pranowo… - Pharmaceuticals, 2021 - mdpi.com
The annual number of cancer deaths continues increasing every day; thus, it is urgent to
search for and find active, selective, and efficient anticancer drugs as soon as possible …

From natural products to new synthetic small molecules: A journey through the world of xanthones

MMM Pinto, A Palmeira, C Fernandes, DISP Resende… - Molecules, 2021 - mdpi.com
This work reviews the contributions of the corresponding author (MMMP) and her research
group to Medicinal Chemistry concerning the isolation from plant and marine sources of …

Xanthones, a promising anti-inflammatory scaffold: Structure, activity, and drug likeness analysis

Z Feng, X Lu, L Gan, Q Zhang, L Lin - Molecules, 2020 - mdpi.com
Inflammation is the body's self-protective response to multiple stimulus, from external
harmful substances to internal danger signals released after trauma or cell dysfunction …

Recent advances in the synthesis of xanthones and azaxanthones

DISP Resende, F Durães, M Maia, E Sousa… - Organic Chemistry …, 2020 - pubs.rsc.org
Xanthones are important O-heteroaromatic tricyclic molecules exhibiting a wide range of
bioactivities and can represent a showcase to highlight the recent techniques and strategies …

Diversity-oriented synthesis of spiropyrrolo [1, 2-a] isoquinoline derivatives via diastereoselective and regiodivergent three-component 1, 3-dipolar cycloaddition …

A Toumi, S Boudriga, K Hamden, I Daoud… - The Journal of …, 2021 - ACS Publications
An efficient diastereoselective route is developed to get access to novel spiropyrrolo [1, 2-a]
isoquinoline-oxindole skeletons by a one-pot three-component [3+ 2] cycloaddition reaction …

[HTML][HTML] Synthetic dimethoxyxanthones bind similarly to human serum albumin compared with highly oxygenated xanthones

OA Chaves, CHC dos Santos Oliveira… - Chemical Physics …, 2024 - Elsevier
Spectroscopic studies were carried out for the interaction of the bioactive compounds 2, 3-
dimethoxyxanthone (1) and 3, 4-dimethoxyxanthone (2) with human serum albumin (HSA) …

Bioactive marine xanthones: A review

JX Soares, DRP Loureiro, AL Dias, S Reis, MMM Pinto… - Marine drugs, 2022 - mdpi.com
The marine environment is an important source of specialized metabolites with valuable
biological activities. Xanthones are a relevant chemical class of specialized metabolites …

Pharmaceuticals, drugs, and resistant microorganisms—environmental impact on population health

T Mackuľak, S Černanský, M Fehér, L Birošová… - Current Opinion in …, 2019 - Elsevier
Pharmaceuticals are indispensable for human and animal health. After use, the active
agents and their metabolites are excreted and impact the environment via different …

Xanthones active against multidrug resistance and virulence mechanisms of bacteria

F Durães, DISP Resende, A Palmeira, N Szemerédi… - Antibiotics, 2021 - mdpi.com
The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to
resist to the action of a wide range of antibiotics is becoming a growing problem for public …