Insects, which lack the adaptive immune system, have developed sophisticated innate
immune system consisting of humoral and cellular immune responses to defend against …

The innate immune response is evolutionary conserved among organisms. The complement
system forms an important and efficient immune defense mechanism. It consists of plasma …

Owing to the genetic similarities and conserved pathways between a fruit fly and mammals,
the use of the Drosophila model as a platform to unveil novel mechanisms of infection and …

In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that
contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo …

Different model systems have, over the years, contributed to our current understanding of the
molecular mechanisms underpinning the various types of interaction between bacteria and …

The entomopathogenic nematodes Heterorhabditis and Steinernema form mutualistic
complexes with Gram-negative bacteria. These insect parasites have emerged as excellent …

Entomopathogenic nematodes (EPNs) have been used in biological control but
improvement is needed to realize their full potential for broader application in agriculture …

Drosophila melanogaster is an outstanding model to study the molecular and functional
basis of host–pathogen interactions. Currently, our knowledge of microbial infections in D …

Highlights•Expansions and losses of immune genes are an important component of
evolutionary change across species.•Transcriptional response to infection involves diverse …

Previous and recent investigations on the innate immune response of Drosophila have
identified certain mechanisms that promote pathogen elimination. However, the function of …