Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc
(IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment …

Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …

Background Icariin (ICA), an active ingredient extracted from Epimedium species, has
shown promising results in the treatment of Alzheimer's disease (AD), although its potential …

Among scaffolds used in tissue engineering, natural biomaterials such as plant-based
materials show a crucial role in cellular function due to their biocompatibility and chemical …

Intervertebral disc degeneration (IVDD) is the most common contributor to low back pain
(LBP). Recent studies have found that oxidative stress and reactive oxygen species (ROS) …

Intervertebral disc degeneration is a natural process of aging. It can cause physical,
psychological, and socioeconomic impact due to the decreasing function of the spine and …

BACKGROUND CONTEXT Lumbar intervertebral disc herniation (LDH) is a common
disease that causes low back pain, radiating leg pain, and sensory impairment. Preclinical …

Animal models have been invaluable in the identification of molecular events occurring in
and contributing to intervertebral disc (IVD) degeneration and important therapeutic targets …

Low back pain is a major cause of disability worldwide that declines the quality of life; it
poses a substantial economic burden for the patient and society. Intervertebral disc (IVD) …

Osteoarthritis (OA) is a common chronic and degenerative joint condition that is mainly
characterized by cartilage degradation, osteophyte formation, and joint stiffness. The NF-κB …