40 Hz light flickering promotes sleep through cortical adenosine signaling

X Zhou, Y He, T Xu, Z Wu, W Guo, X Xu, Y Liu, Y Zhang… - Cell Research, 2024 - nature.com
Flickering light stimulation has emerged as a promising non-invasive neuromodulation
strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical …

Ubiquitin proteasome system and glaucoma: A survey of genetics and molecular biology studies supporting a link with pathogenic and therapeutic relevance

I Pandino, S Giammaria, GA Zingale, G Roberti… - Molecular Aspects of …, 2023 - Elsevier
Glaucoma represents a group of progressive neurodegenerative diseases characterized by
the loss of retinal ganglion cells (RGCs) and their axons with subsequent visual field …

10 Years of GWAS in intraocular pressure

XR Gao, M Chiariglione, H Choquet, AJ Arch - Frontiers in Genetics, 2023 - frontiersin.org
Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma, the leading cause
of irreversible blindness worldwide. In this review, we summarize the findings of genome …

[HTML][HTML] Open angle glaucoma

N Mahabadi, LA Foris, K Tripathy - 2017 - europepmc.org
Objectives: Identify the risk factors for open-angle glaucoma. Explain how to diagnose open-
angle glaucoma. Summarize the treatment options available for patients with open-angle …

Integration of variant annotations using deep set networks boosts rare variant association testing

B Clarke, E Holtkamp, H Öztürk, M Mück, M Wahlberg… - Nature Genetics, 2024 - nature.com
Rare genetic variants can have strong effects on phenotypes, yet accounting for rare
variants in genetic analyses is statistically challenging due to the limited number of allele …

Causal association between iritis or uveitis and glaucoma: a two-sample Mendelian randomisation study

JH Seo, Y Lee - Genes, 2023 - mdpi.com
Recent studies have suggested an association between iritis or uveitis and glaucoma. This
study investigated the causal relationship between glaucoma and iritis and uveitis as …

Magneto-elastic for wireless intraocular pressure monitoring

Y Lin, S Xiang, W Zou, X Chen, F Gao, Y Liu… - Chemical Engineering …, 2024 - Elsevier
Increased intraocular pressure (IOP) can lead to optic nerve damage and various ocular
diseases, including glaucoma, which is the primary cause of irreversible blindness. Thus …

Increasing the diagnostic yield of childhood glaucoma cases recruited into the 100,000 Genomes Project

O Al-Saei, S Malka, N Owen, E Aliyev, FR Vempalli… - BMC genomics, 2024 - Springer
Childhood glaucoma (CG) encompasses a heterogeneous group of genetic eye disorders
that is responsible for approximately 5% of childhood blindness worldwide. Understanding …

ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation

S Paquay, J Duraffourd, M Bury, IP Heremans… - Cellular and Molecular …, 2024 - Springer
Hydroxylated fatty acids are important intermediates in lipid metabolism and signaling.
Surprisingly, the metabolism of 4-hydroxy fatty acids remains largely unexplored. We found …

[HTML][HTML] Structural framework to address variant-gene relationship in primary open-angle glaucoma

N Singh, K Kizhatil, D Duraikannu, H Choquet, KS Nair - Vision Research, 2025 - Elsevier
Primary open-angle glaucoma (POAG) is a complex, multifactorial disease leading to
progressive optic neuropathy and irreversible vision loss. Genome-Wide Association …