Animal cells use a conserved repertoire of intercellular signaling pathways to communicate
with one another. These pathways are well-studied from a molecular point of view. However …

Cells in diverse organisms can store the information of previous environmental conditions
for long periods of time. This form of cellular memory adjusts the cell's responses to future …

From bacteria to humans, individual cells within isogenic populations can show significant
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …

While it has been established that the responses of T cells to antigens are combinatorially
regulated by multiple signaling pathways, it remains elusive what mechanisms cells utilize to …

Species pairs often become genetically incompatible during divergence, which is an
important source of reproductive isolation. An idealized picture is often painted where …

Cells decide when, where, and to what level to express their genes by" computing"
information from transcription factors (TFs) binding to regulatory DNA. How is the information …

Gene expression is thought to be affected not only by the concentration of transcription
factors (TFs) but also the dynamics of their nuclear translocation. Testing this hypothesis …

Gene duplication promotes adaptive evolution in two main ways: allowing one duplicate to
evolve a new function and splitting ancestral functions between the duplicates. The second …

Gene-regulatory networks achieve complex mappings of inputs to outputs through
mechanisms that are poorly understood. We found that in the galactose-responsive pathway …

Motivation The gene regulatory process resembles a logic system in which a target gene is
regulated by a logic gate among its regulators. While various computational techniques are …