Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment

JM Llovet, CE Willoughby, AG Singal… - Nature reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …

Role of insulin resistance in MAFLD

Y Sakurai, N Kubota, T Yamauchi… - International journal of …, 2021 - mdpi.com
Many studies have reported that metabolic dysfunction is closely involved in the complex
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …

[HTML][HTML] Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

PK Luukkonen, S Qadri, N Ahlholm, K Porthan… - Journal of …, 2022 - Elsevier
Background & Aims There is substantial inter-individual variability in the risk of non-alcoholic
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …

Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity

WJ Valentine, K Yanagida, H Kawana, N Kono… - Journal of Biological …, 2022 - ASBMB
The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …

Metabolic dysfunction–associated fatty liver disease and the risk of 24 specific cancers

Z Liu, C Lin, C Suo, R Zhao, L Jin, T Zhang, X Chen - Metabolism, 2022 - Elsevier
Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a significant
health issue closely associated with multiple metabolic dysfunctions. The association …

New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease

VB O'Donnell - Biochemical Society Transactions, 2022 - portlandpress.com
The Lands Pathway is a fundamental biochemical process named for its discovery by
William EM Lands and revealed in a series of seminal papers published in the Journal of …

[HTML][HTML] Aktualisierte S2k-Leitlinie nicht-alkoholische Fettlebererkrankung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs-und …

E Roeb, A Canbay, H Bantel, J Bojunga… - Zeitschrift für …, 2022 - thieme-connect.com
Das Fortschreiten einer NASH ist assoziiert mit Leberzellstress, konsekutiver Entzündung
und Fibrose, mit potentieller Entwicklung einer Leberzirrhose, portaler Hypertension und der …

[PDF][PDF] Genome‐Wide association study of NAFLD using electronic health records

CJ Fairfield, TM Drake, R Pius… - Hepatology …, 2022 - Wiley Online Library
Genome‐wide association studies (GWAS) have identified several risk loci for nonalcoholic
fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and …

Machine learning enables new insights into genetic contributions to liver fat accumulation

ME Haas, JP Pirruccello, SN Friedman, M Wang… - Cell genomics, 2021 - cell.com
Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease
and cardiometabolic diseases but often remains undiagnosed in clinical practice because of …

Genetics is of the essence to face NAFLD

M Meroni, M Longo, G Tria, P Dongiovanni - Biomedicines, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease
worldwide. It is closely related to obesity, insulin resistance (IR) and dyslipidemia so much …