A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

Organoids are being widely introduced as novel research models in multiple research fields.
Human-induced pluripotent stem cells-derived kidney organoids became an indispensable …

COVID-19 infection causes collapse of glomerular capillaries and loss of podocytes,
culminating in a severe kidney disease called COVID-19–associated nephropathy …

Kidney organoids differentiated from pluripotent stem cells are powerful models of kidney
development and disease but are characterized by cell immaturity and off-target cell fates …

People of recent sub-Saharan African ancestry develop kidney failure much more frequently
than other groups. A large fraction of this disparity is due to two coding sequence variants in …

Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection
remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited …

Purpose of Review: To understand the impact of kidney disease in Canada and the priority
areas of kidney research that can benefit from patient-oriented, precision medicine research …

Background Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly
associated with African ancestry are major contributors to the large racial disparity in rates of …

Optimization of cell engineering protocols requires standard, comprehensive quality metrics.
We previously developed CellNet, a computational tool to quantitatively assess the …

In humans, insulin resistance is a physiological response to infections developed to supply
sufficient energy to the activated immune system. This metabolic adaptation facilitates the …