Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …

PHD (plant homeodomain) zinc fingers are structurally conserved modules found in proteins
that modify chromatin as well as mediate molecular interactions in gene transcription. The …

More than 15 years ago, mutations in the autoimmune regulator (AIRE) gene were identified
as the cause of autoimmune polyglandular syndrome type 1 (APS1). It is now clear that this …

The combinatorial pattern of DNA and histone modifications constitutes an epigenetic 'code
'that shapes gene-expression patterns by enabling or restricting the transcriptional potential …

About two decades ago, cloning of the autoimmune regulator (AIRE) gene materialized one
of the most important actors on the scene of self-tolerance. Thymic transcription of genes …

The roles of post-translational histone modifications in regulating transcription and DNA
damage have been widely studied and discussed. Although mitotic histone marks …

Plant homeodomain (PHD) fingers have emerged as one of the largest families of epigenetic
effectors capable of recognizing or 'reading'post-translational histone modifications and …

A major challenge in chromatin biology is to understand the mechanisms by which
chromatin is remodeled into active or inactive states as required during development and …

In the thymus, developing T cells that react against self-antigens with high affinity are
deleted in the process of negative selection. An essential component of this process is the …

Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA)
in thymic medullary epithelial cells (MECs), driving immunological self-tolerance in …