Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

Neutrophils have traditionally been thought of as simple foot soldiers of the innate immune
system with a restricted set of pro-inflammatory functions. More recently, it has become …

'Leaky gut'syndrome, long-associated with celiac disease, has attracted much attention in
recent years and for decades, was widely known in complementary/alternative medicine …

The complement activation product C3a is often described as a proinflammatory mediator,
alongside its downstream cousin, C5a. However, emerging studies show that C3a has …

Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally
identified as a growth factor for early stage B cells. We show here that PBEF is also …

Mucosal repair is a complex event that immediately follows acute injury induced by ischemia
and noxious luminal contents such as bile. In the small intestine, villous contraction is the …

The accumulation of leukocytes in inflamed tissue results from adhesive interactions
between leukocytes and endothelial cells within the microcirculation. These adhesive …

The microbiota of Westerners is significantly reduced in comparison to rural individuals
living a similar lifestyle to our Paleolithic forefathers but also to that of other free-living …

Research in the field of ischemia-reperfusion injury continues to be plagued by the inability
to translate research findings to clinically useful therapies. This may in part relate to the …