Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

Thousands of genes are being discovered for the first time by sequencing the genomes of
model organisms, an exhilarating reminder that much of the natural world remains to be …

The success of fluorescence experiments requires attention to experimental details and an
understanding of the instrumentation. There are also many potential artifacts that can distort …

▪ Abstract In this review, recent advances in DNA microarray technology and their
applications are examined. The many varieties of DNA microarray or DNA chip devices and …

Experimental genomics involves taking advantage of sequence information to investigate
and understand the workings of genes, cells and organisms. We have developed an …

We synthesized multimetal microrods intrinsically encoded with submicrometer stripes.
Complex striping patterns are readily prepared by sequential electrochemical deposition of …

Mice carrying a null mutation in the Period 1 (mPer1) gene were generated using embryonic
stem cell technology. Homozygous mPer1 mutants display a shorter circadian period with …

Background: The recent flood of data from genome sequences and functional genomics has
given rise to new field, bioinformatics, which combines elements of biology and computer …

Abstract cDNA microarrays are capable of profiling gene expression patterns of tens of
thousands of genes in a single experiment. DNA targets, in the form of 3 expressed …

A new approach to ultrasensitive detection of DNA hybridization based on nanoparticle-
amplified surface plasmon resonance (SPR) is described. Use of the Au nanoparticle tags …