[HTML][HTML] Selective autophagy of intracellular organelles: recent research advances
Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …
that degrades over-abundant or damaged organelles, large protein aggregates and …
ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum
F Reggiori, M Molinari - Physiological reviews, 2022 - journals.physiology.org
ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …
The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma
Somatic copy number variations (CNV) may drive cancer progression through both coding
and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely …
and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely …
Autophagy and organelle homeostasis in cancer
DR Miller, A Thorburn - Developmental cell, 2021 - cell.com
Beginning with the earliest studies of autophagy in cancer, there have been indications that
autophagy can both promote and inhibit cancer growth and progression; autophagy …
autophagy can both promote and inhibit cancer growth and progression; autophagy …
Hypoxia and selective autophagy in cancer development and therapy
Low oxygen availability, a condition known as hypoxia, is a common feature of various
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
F Fumagalli, J Noack, TJ Bergmann, E Cebollero… - Nature cell …, 2016 - nature.com
The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …
ER homeostasis activates stress programs collectively called the unfolded protein response …
An update on Sec61 channel functions, mechanisms, and related diseases
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …
protein translocon, which facilitates membrane integration or translocation of almost every …
Let's talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
M Linxweiler, B Schick, R Zimmermann - Signal transduction and …, 2017 - nature.com
The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …
Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives
J Liu, Y Wu, S Meng, P Xu, S Li, Y Li, X Hu, L Ouyang… - Molecular cancer, 2024 - Springer
Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …