Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …

Glial cells are non-neuronal cells in the nervous system that are crucial for proper brain
development and function. Three major classes of glia in the central nervous system (CNS) …

Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to
active signaling and information processing in the brain. Contrary to this classical view, it is …

Astrocytes play active roles in brain physiology by dynamic interactions with neurons.
Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved …

Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric
diseases, and that glial cells participate in synapse formation, development, and plasticity …

Control of the glutamate time course in the synapse is crucial for excitatory transmission.
This process is mainly ensured by astrocytic transporters, high expression of which is …

Several structural and cellular changes, including marked glial anomalies, have been
observed in association with major depressive disorder. Here we review these cellular …

Altered glutamate transporter expression is a common feature of many neuropsychiatric
conditions, including schizophrenia. Excitatory amino acid transporters (EAATs) are …

Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

Activity-dependent long-term changes in synaptic transmission known as synaptic plasticity
are fundamental processes in brain function and are recognized as the cellular basis of …