SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel
nucleosomes and to modulate transcription. Growing evidence indicates that these …

Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …

Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is
extremely prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid …

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms …

Liver tumors are rare in children, and their diagnoses may be challenging particularly
because of the lack of a current consensus classification system. Systematic central …

SMARCB 1/INI 1 is one of the core subunit proteins of the ATP‐dependent SWI/SNF
chromatin remodeling complex, and is identified as a potent and bona fide tumor …

In Europe, almost 1000 children are diagnosed with a malignant renal tumour each year.
The vast majority of cases are nephroblastoma, also known as Wilms' tumour (WT). Most …

SWI/SNF chromatin remodeling complexes are pleomorphic multisubunit cellular machines
that utilize the energy of ATP hydrolysis to modulate chromatin structure. The complexes …

Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of …

Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …