Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of
individuals to diseases. All individuals have DNA risk variants for all common diseases, but …

Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date
(n= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …

Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …

Importance Increasing evidence shows that physical activity is associated with reduced risk
for depression, pointing to a potential modifiable target for prevention. However, the …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …

Single-cell technologies measure unique cellular signatures but are typically limited to a
single modality. Computational approaches allow the fusion of diverse single-cell data …