Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement
ZH Gray, D Chakraborty, RR Duttweiler, GD Alekbaeva… - Cell, 2023 - cell.com
Summary MLL/KMT2A amplifications and translocations are prevalent in infant, adult, and
therapy-induced leukemia. However, the molecular contributor (s) to these alterations are …
therapy-induced leukemia. However, the molecular contributor (s) to these alterations are …
The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection
Topoisomerases are essential for the replication of herpesviruses but the mechanisms by
which the viruses hijack the cellular enzymes are largely unknown. We found that …
which the viruses hijack the cellular enzymes are largely unknown. We found that …
Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia
G Zagnoli-Vieira, J Brazina, K Van Den Bogaert… - Human Genetics, 2023 - Springer
Mutations in TDP2, encoding tyrosyl-DNA phosphodiesterase 2, have been associated with
a syndromal form of autosomal recessive spinocerebellar ataxia, type 23 (SCAR23). This is …
a syndromal form of autosomal recessive spinocerebellar ataxia, type 23 (SCAR23). This is …
Topoisomerase 2β induces DNA breaks to regulate human papillomavirus replication
P Kaminski, S Hong, T Kono, P Hoover, L Laimins - MBio, 2021 - Am Soc Microbiol
Topoisomerases regulate higher-order chromatin structures through the transient breaking
and religating of one or both strands of the phosphodiester backbone of duplex DNA. TOP2β …
and religating of one or both strands of the phosphodiester backbone of duplex DNA. TOP2β …
[PDF][PDF] Insights into the formation of oncogenic chromosome rearrangements
V Minneker - 2022 - openscience.ub.uni-mainz.de
Chromosomal rearrangements like translocations can directly induce cancerogenesis. They
occur very rarely but can give a growth advantage, which makes the steps required for their …
occur very rarely but can give a growth advantage, which makes the steps required for their …
The Epstein-Barr virus ubiquitin deconjugase BPLF1 regulates the activity of Topoisomerase II during virus replication
Topoisomerases are essential for the replication of herpesviruses but the mechanisms by
which the viruses hijack the cellular enzymes are largely unknown. We found that …
which the viruses hijack the cellular enzymes are largely unknown. We found that …