Antimicrobial peptides and copper (II) ions: Novel therapeutic opportunities
J Portelinha, SS Duay, SI Yu, K Heilemann… - Chemical …, 2021 - ACS Publications
The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …
health issue that requires the development of novel classes of antibiotics. Antimicrobial …
LEAP-2: an emerging endogenous ghrelin receptor antagonist in the pathophysiology of obesity
Liver-expressed antimicrobial peptide 2 (LEAP-2), originally described as an antimicrobial
peptide, has recently been recognized as an endogenous blocker of growth hormone …
peptide, has recently been recognized as an endogenous blocker of growth hormone …
[HTML][HTML] LEAP2 is an endogenous antagonist of the ghrelin receptor
X Ge, H Yang, MA Bednarek, H Galon-Tilleman… - Cell metabolism, 2018 - cell.com
Ghrelin, an appetite-stimulatory hormone secreted by the stomach, was discovered as a
ligand for the growth hormone secretagogue receptor (GHSR). Through GHSR, ghrelin …
ligand for the growth hormone secretagogue receptor (GHSR). Through GHSR, ghrelin …
LEAP2 changes with body mass and food intake in humans and mice
Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …
[HTML][HTML] LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue
Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …
Identifying the binding mechanism of LEAP 2 to receptor GHSR 1a
JH Wang, HZ Li, XX Shao, WH Nie, YL Liu… - The FEBS …, 2019 - Wiley Online Library
Liver‐expressed antimicrobial peptide 2 (LEAP 2) is a highly conserved secretory peptide
first isolated in 2003. However, its exact biological functions remained elusive until a recent …
first isolated in 2003. However, its exact biological functions remained elusive until a recent …
New insights into the antimicrobial mechanism of LEAP2 mutant zebrafish under Aeromonas hydrophila infection using transcriptome analysis
Y Fei, Q Wang, J Lu, L Ouyang, Q Hu, L Chen - Fish & Shellfish Immunology, 2023 - Elsevier
Liver-expressed antimicrobial peptide 2 (LEAP2) is a blood-derived antimicrobial peptide
expressed predominantly in the liver. Although LEAP2 has been reported to exert …
expressed predominantly in the liver. Although LEAP2 has been reported to exert …
Ghrelin and LEAP-2: rivals in energy metabolism
Liver-expressed antimicrobial peptide 2 (LEAP-2), the endogenous noncompetitive
allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a), was …
allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a), was …
The ups and downs of growth hormone secretagogue receptor signaling
The growth hormone secretagogue receptor (GHSR) has emerged as one of the most
fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly …
fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly …
Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer …
SM Rachidi, T Qin, S Sun, WJ Zheng, Z Li - PloS one, 2013 - journals.plos.org
Background Immune evasion is one of the recognized hallmarks of cancer. Inflammatory
responses to cancer can also contribute directly to oncogenesis. Since the immune system …
responses to cancer can also contribute directly to oncogenesis. Since the immune system …