[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
Mitofusin 2: from functions to disease
Mitochondria are highly dynamic organelles whose functions are essential for cell viability.
Within the cell, the mitochondrial network is continuously remodeled through the balance …
Within the cell, the mitochondrial network is continuously remodeled through the balance …
Metabolic control of cell death
Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …
been considered two independent entities. On one side stood the catabolic and anabolic …
MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A
Mitofusins (MFNs) promote fusion-mediated mitochondrial content exchange and
subcellular trafficking. Mutations in Mfn2 cause neurodegenerative Charcot-Marie-Tooth …
subcellular trafficking. Mutations in Mfn2 cause neurodegenerative Charcot-Marie-Tooth …
Mitochondria, oxidative stress and neurodegeneration
A Federico, E Cardaioli, P Da Pozzo, P Formichi… - Journal of the …, 2012 - Elsevier
Mitochondria are involved in ATP supply to cells through oxidative phosphorylation
(OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in …
(OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in …
Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity
AM Bertholet, T Delerue, AM Millet, MF Moulis… - Neurobiology of …, 2016 - Elsevier
Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …
balance of fusion and fission of mitochondria determines their morphology and allows their …
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
D Sebastián, MI Hernández-Alvarez… - Proceedings of the …, 2012 - National Acad Sciences
Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal
mitochondrial function is ensured by a quality-control system tightly coupled to fusion and …
mitochondrial function is ensured by a quality-control system tightly coupled to fusion and …
Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases
H Chen, DC Chan - Human molecular genetics, 2009 - academic.oup.com
Neurons are metabolically active cells with high energy demands at locations distant from
the cell body. As a result, these cells are particularly dependent on mitochondrial function …
the cell body. As a result, these cells are particularly dependent on mitochondrial function …
Mitochondrial dynamics in mammalian health and disease
The meaning of the word mitochondrion (from the Greek mitos, meaning thread, and
chondros, grain) illustrates that the heterogeneity of mitochondrial morphology has been …
chondros, grain) illustrates that the heterogeneity of mitochondrial morphology has been …
Structure, function, and regulation of mitofusin‐2 in health and disease
Mitochondria are highly dynamic organelles that constantly migrate, fuse, and divide to
regulate their shape, size, number, and bioenergetic function. Mitofusins (Mfn1/2), optic …
regulate their shape, size, number, and bioenergetic function. Mitofusins (Mfn1/2), optic …