Septic shock, the most severe complication of sepsis, is a deadly disease. In recent years,
exciting advances have been made in the understanding of its pathophysiology and …

▪ Abstract Covalent attachment of activated complement C3 (C3d) to antigen links innate and
adaptive immunity by targeting antigen to follicular dendritic cells (FDC) and B cells via …

Sepsis is a major clinical problem for which therapeutic interventions have been largely
unsuccessful, in spite of promising strategies that were successful in animals, especially …

The generation of autoantibody and subsequent tissue deposition of immune complexes
(IC) is thought to trigger the pathogenic consequences of systemic autoimmune disease …

Broadly speaking, C1 inhibitor plays important roles in the regulation of vascular
permeability and in the suppression of inflammation. Vascular permeability control is exerted …

Sepsis in humans is a difficult condition to treat and is often associated with a high mortality
rate. In this study, we induced sepsis in rats using cecal ligation and puncture (CLP). In rats …

▪ Abstract Recent results obtained in mice deficient in either FcRs or complement have
revealed distinct functions for these two classes of molecules. While each is capable of …

Infections with gram-positive bacteria are a major cause of morbidity and mortality in
humans. Opsonin-dependent phagocytosis plays a major role in protection against and …

In humans with sepsis, the onset of multiorgan failure (MOF), especially involving liver,
lungs, and kidneys, is a well known complication that is associated with a high mortality rate …

The innate immune system is activate by pathogens or environmental antigens following
their binding by recognition melocules such as mannan-binding lectin, C-reactive protein …