Microbial translocation in the pathogenesis of HIV infection and AIDS
G Marchetti, C Tincati, G Silvestri - Clinical microbiology reviews, 2013 - Am Soc Microbiol
In pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus
(HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to …
(HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to …
Immune activation and HIV persistence: implications for curative approaches to HIV infection
NR Klatt, N Chomont, DC Douek… - Immunological …, 2013 - Wiley Online Library
Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …
replication with combination antiretroviral therapy, both HIV and chronic …
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
Progressive HIV infection is characterized by dysregulation of the intestinal immune barrier,
translocation of immunostimulatory microbial products, and chronic systemic inflammation …
translocation of immunostimulatory microbial products, and chronic systemic inflammation …
Pathogenic mechanisms of HIV disease
Human immunodeficiency virus (HIV) infection is generally characterized by inefficient viral
transmission; an acute phase of intense viral replication and dissemination to lymphoid …
transmission; an acute phase of intense viral replication and dissemination to lymphoid …
Emerging concepts in the immunopathogenesis of AIDS
DC Douek, M Roederer, RA Koup - Annual review of medicine, 2009 - annualreviews.org
There is an intense interplay between HIV and the immune system, and the literature is
replete with studies describing various immunological phenomena associated with HIV …
replete with studies describing various immunological phenomena associated with HIV …
Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections
JD Estes, LD Harris, NR Klatt, B Tabb… - PLoS …, 2010 - journals.plos.org
The chronic phase of HIV infection is marked by pathological activation of the immune
system, the extent of which better predicts disease progression than either plasma viral load …
system, the extent of which better predicts disease progression than either plasma viral load …
Residual immune dysregulation syndrome in treated HIV infection
MM Lederman, NT Funderburg, RP Sekaly… - Advances in …, 2013 - Elsevier
Antiretroviral therapy has revolutionized the course of HIV infection, improving immune
function and decreasing dramatically the mortality and morbidity due to the opportunistic …
function and decreasing dramatically the mortality and morbidity due to the opportunistic …
Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz
African primates are naturally infected with over 40 different simian immunodeficiency
viruses (SIVs), two of which have crossed the species barrier and generated human …
viruses (SIVs), two of which have crossed the species barrier and generated human …
Natural SIV hosts: showing AIDS the door
Many species of African nonhuman primates are naturally infected with simian
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys
Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus
replication. Strikingly, it is characterized by low levels of immune activation, while …
replication. Strikingly, it is characterized by low levels of immune activation, while …