Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox
system, encompassing pro-oxidative proteins and antioxidative proteins. These proteins …

Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular
intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of …

Ferroptosis therapy has emerged as a promising strategy for cancer treatment due to its
unique cell death mechanism and tumor targeting. However, for colorectal cancer (CRC) …

Diacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol and converts it into
phosphatidic acid. DGKδ contributes to glucose uptake as one of its cellular functions …

Medulloblastoma (MB) is the most common malignant brain tumor in children, typically
arising during infancy and childhood. Despite multimodal therapies achieving a response …

Abstract STAM Binding Protein Like 1 (STAMBPL1), functions as a deubiquitinase (DUB)
and plays a significant role in various types of cancers. However, its effect as a DUB …

Ferroptosis is a type of cell death that is caused by the oxidation of lipids and is dependent
on the presence of iron. It was first characterized by Brent R. Stockwell in 2012, and since …

Aim To construct and identify a prognostic and therapeutic signature based on disulfidptosis-
related genes in lung adenocarcinoma. Methods Bioinformatic analysis was performed to …

Regulated cell death (RCD) is a controlled form of cell death orchestrated by one or more
cascading signaling pathways, making it amenable to pharmacological intervention. RCD …

As non-degradative enzymes, ubiquitin-specific proteases, comprised a wide class of
deubiquitinating enzymes, regulate several signaling pathways and other functions to confer …