From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Connecting the dots: investigating the link between environmental, genetic, and epigenetic influences in metabolomic alterations in oral squamous cell carcinoma

I Gupta, F Badrzadeh, Y Tsentalovich… - Journal of Experimental & …, 2024 - Springer
Oral squamous cell carcinoma (OSCC) accounts for around 90% of all oral cancers and is
the eighth most common cancer worldwide. Despite progress in managing OSCC, the …

Facile and compact electrochemical paper-based analytical device for point-of-care diagnostic of dual carcinogen oxidative stress biomarkers through a molecularly …

M Amatatongchai, N Nontawong, P Ngaosri… - Analytical …, 2022 - ACS Publications
Nanoscale imprinting significantly increases the specific surface area and recognition
capabilities of a molecularly imprinted polymer by improving accessibility to analytes …

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

I Sequeira, M Rashid, IM Tomás, MJ Williams… - Nature …, 2020 - nature.com
To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the
heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed …

Extreme sensitivity to ultraviolet light in the fungal pathogen causing white-nose syndrome of bats

JM Palmer, KP Drees, JT Foster, DL Lindner - Nature Communications, 2018 - nature.com
Bat white-nose syndrome (WNS), caused by the fungal pathogen Pseudogymnoascus
destructans, has decimated North American hibernating bats since its emergence in 2006 …

Discovery of McrA, a master regulator of Aspergillus secondary metabolism

CE Oakley, M Ahuja, WW Sun, R Entwistle… - Molecular …, 2017 - Wiley Online Library
Fungal secondary metabolites (SMs) are extremely important in medicine and agriculture,
but regulation of their biosynthesis is incompletely understood. We have developed a …

A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy

S Ueda, S Yamashita, M Nakajima… - Proceedings of the …, 2022 - National Acad Sciences
Somatic mutations are accumulated in normal human tissues with aging and exposure to
carcinogens. If we can accurately count any passenger mutations in any single DNA …

Conidiation under illumination enhances conidial tolerance of insect-pathogenic fungi to environmental stresses

LP Dias, RKF Souza, B Pupin, DEN Rangel - Fungal Biology, 2021 - Elsevier
Light is an important signal for fungi in the environment and induces many genes with roles
in stress and virulence responses. Conidia of the entomopathogenic fungi Aschersonia …

Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus Aspergillus

BT Pfannenstiel, X Zhao, J Wortman, P Wiemann… - MBio, 2017 - Am Soc Microbiol
The study of aflatoxin in Aspergillus spp. has garnered the attention of many researchers
due to aflatoxin's carcinogenic properties and frequency as a food and feed contaminant …

4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma

SH Sagheer, D Whitaker-Menezes, JYS Han… - Methods in Cell …, 2021 - Elsevier
Oral squamous cell carcinoma (OSCC) is the most common subsite of head and neck
cancer, with a 5-year survival rate of only 50%. There is a pressing need for animal models …