In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Although it is a rare disease, the number of available therapeutic options for treating
pulmonary arterial hypertension has increased since the late 1990s, with multiple drugs …

Pulmonary hypertension is a progressive and often fatal cardiopulmonary condition
characterised by increased pulmonary arterial pressure, structural changes in the pulmonary …

Introduction Pulmonary arterial hypertension (PAH) is a progressive and life-threatening
disease. Approved treatment options currently primarily target abnormal cell signaling …

Background Pulmonary arterial hypertension (PAH) encompasses a group of diseases
characterized by raised pulmonary vascular resistance, resulting from vascular remodelling …

Pulmonary arterial hypertension (PAH) is a severe condition with a high mortality rate
despite advances in diagnostic and therapeutic strategies. In recent years, significant …

A major gap in diagnosis, classification, risk stratification, and prediction of therapeutic
response exists in pulmonary arterial hypertension (PAH), driven in part by a lack of …

Bromodomain and extra-terminal domain (BET) proteins are epigenetic modulators that
regulate gene transcription through interacting with acetylated lysine residues of histone …

Lysine acetylation is a major post-translational modification in histones and other proteins
that is catalysed by the 'writer'lysine acetyltransferases (KATs) and mediates interactions …