Immunotherapy, despite its promise for future anti-cancer approach, faces significant
challenges, such as off-tumor side effects, innate or acquired resistance, and limited …

Mechanical stimuli have rather ambiguous and less‐specific features among various
physical stimuli, but most materials exhibit a certain level of responses upon mechanical …

Recent cumulative findings signify the adaptive immunity of materials as a key agenda in
tissue healing that can improve regenerative events and outcomes. Modulating immune …

Cell-surface receptors mediate communication between cells and their environment. Lateral
membrane organization and dynamic receptor cluster formation are fundamental in signal …

T cells typically recognize their ligands using a defined cell biology—the scanning of their
membrane microvilli (MV) to palpate their environment—while that same membrane …

Chimeric antigen receptor (CAR)-T cells form dynamic immunological synapses with their
cancer cell targets. After a CAR-antigen engagement, the CAR-T synapse forms, matures …

The tumor microenvironment (TME) plays a pivotal role in the behavior and development of
solid tumors as well as shaping the immune response against them. As the tumor cells …

Oral administration of pharmaceuticals is the most preferred route of administration for
patients, but it is challenging to effectively deliver active ingredients (APIs) that i) have …

Although T cell activation is known to involve the internalization of the T cell antigen receptor
(TCR), much less is known regarding the release of TCRs following T cell interaction with …

Efficient scanning of tissue that T cells encounter during their migratory life is pivotal to
protective adaptive immunity. In fact, T cells can detect even a single antigenic peptide/MHC …