Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Eukaryotic cells express a family of eukaryotic translation initiation factor 2 alpha (eIF2α)
kinases (eg, PKR, PERK-PEK, GCN2, HRI) that are individually activated in response to …

Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are
assembled into discrete granules by specific RNA-binding proteins such as G3BP. We now …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that
harbor non-translating mRNAs bound by various proteins that regulate mRNA translation …

Cellular states are determined by differential expression of the cell's proteins. The
relationship between protein and mRNA expression levels informs about the combined …

Innate immune responses combat infectious microorganisms by inducing inflammatory
responses, antimicrobial pathways and adaptive immunity. Multiple genes within each of …

Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

We report here that miR-155 and miR-125b play a role in innate immune response. LPS
stimulation of mouse Raw 264.7 macrophages resulted in the up-regulation of miR-155 and …