Here we discuss the role of diverse environmental manipulations affecting cognition with
special regard to psychiatric conditions. We present evidence supporting a direct causal …

Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult
brain and functions as both a primary neurotrophic signal and a neuromodulator. It serves …

Background Depression, one of the most common mental illnesses and mood disorder
syndromes, can seriously harm physical and mental health. As the pathophysiology of …

Mitochondrial dysfunction has been reported to be involved in the pathogenesis of
depression, and mitophagy is a key pathway for mitochondrial quality control. This study …

Significant efforts are increasingly directed towards identifying novel therapeutic targets for
autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in …

Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …

Depressive disorders (DDs) are an increasingly common health problem that affects all age
groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the …

Post-traumatic stress disorder (PTSD) is a trauma-related condition that produces
distressing fear memory intrusions, avoidance behaviors, hyperarousal, stress responses …

Background N-methyl-d-aspartate receptor (NMDAR) has been implicated in the
pathophysiology of depression. However, as the unique inhibitory subunit of NMDARs, the …

Traxoprodil is a selective N‐methyl‐d‐aspartate receptor subunit 2B (NR2B) receptor
inhibitor with rapid and long‐lasting antidepressant effects. However, the appropriate …