The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …

The transcription factor NF-κB has served as a standard for inducible transcription factors for
more than 20 years. The numerous stimuli that activate NF-κB, and the large number of …

The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …

The IKK kinase complex is the core element of the NF-κB cascade. It is essentially made of
two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. Additional components …

Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell
stress response, the unfolded protein response, which is aimed initially at compensating for …

Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key component in
NF-κB signalling triggered by TNF-α,. Genetic evidence indicates that TRAF2 is necessary …

The inhibitor of apoptosis (IAP) family of proteins enhances cell survival through
mechanisms that remain uncertain. In this report, we show that cIAP1 and cIAP2 promote …

The transcription factor NF-κB (nuclear factor kappa enhancer binding protein) controls
many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates …

NF-κB, a transcription factor, becomes activated during the Unfolded Protein Response
(UPR), an endoplasmic reticulum (ER) stress response pathway. NF-κB is normally held …

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular
proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic …