Interactions between Borrelia burgdorferi and ticks

C Kurokawa, GE Lynn, JHF Pedra, U Pal… - Nature Reviews …, 2020 - nature.com
Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate
hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic …

Lyme disease pathogenesis

J Coburn, B Garcia, LT Hu, MW Jewett… - Current issues in …, 2021 - mdpi.com
Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

The effect of bacterial chemotaxis on host infection and pathogenicity

MA Matilla, T Krell - FEMS Microbiology Reviews, 2018 - academic.oup.com
Chemotaxis enables microorganisms to move according to chemical gradients. Although
this process requires substantial cellular energy, it also affords key physiological benefits …

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

JD Radolf, MJ Caimano, B Stevenson… - Nature reviews …, 2012 - nature.com
In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia
burgdorferi, has risen from relative obscurity to become a global public health problem and a …

Hijacking factor H for complement immune evasion

SR Moore, SS Menon, C Cortes… - Frontiers in …, 2021 - frontiersin.org
The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

Biology of infection with Borrelia burgdorferi

K Tilly, PA Rosa, PE Stewart - Infectious disease clinics of North America, 2008 - Elsevier
The spirochete Borrelia burgdorferi is a tick-borne obligate parasite whose normal reservoir
is a variety of small mammals. Although infection of these natural hosts does not lead to …

Physiological Osmotic Induction of Leptospira interrogans Adhesion: LigA and LigB Bind Extracellular Matrix Proteins and Fibrinogen

HA Choy, MM Kelley, TL Chen, AK Møller… - Infection and …, 2007 - Am Soc Microbiol
Transmission of leptospirosis occurs through contact of mucous membranes and abraded
skin with freshwater contaminated by pathogenic Leptospira spp. Exposure to physiological …

The role of Borrelia burgdorferi outer surface proteins

MR Kenedy, TR Lenhart… - FEMS Immunology & …, 2012 - academic.oup.com
Human pathogenic spirochetes causing Lyme disease belong to the Borrelia burgdorferi
sensu lato complex. Borrelia burgdorferi organisms are extracellular pathogens transmitted …

The unique paradigm of spirochete motility and chemotaxis

NW Charon, A Cockburn, C Li, J Liu… - Annual review of …, 2012 - annualreviews.org
Spirochete motility is enigmatic: It differs from the motility of most other bacteria in that the
entire bacterium is involved in translocation in the absence of external appendages. Using …

Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host

TJ Moriarty, MU Norman, P Colarusso… - PLoS …, 2008 - journals.plos.org
Pathogenic spirochetes are bacteria that cause a number of emerging and re-emerging
diseases worldwide, including syphilis, leptospirosis, relapsing fever, and Lyme borreliosis …