Ratcheting synthesis

S Borsley, JM Gallagher, DA Leigh… - Nature Reviews …, 2024 - nature.com
Synthetic chemistry has traditionally relied on reactions between reactants of high chemical
potential and transformations that proceed energetically downhill to either a global or local …

Opportunities and challenges in microbial medium chain fatty acids production from waste biomass

Q Wu, Y Jiang, Y Chen, M Liu, X Bao, W Guo - Bioresource technology, 2021 - Elsevier
Medium chain fatty acids (MCFAs) that produced from affordable waste biomass via chain
elongation (CE) technology are recognized as the potential alternatives to part fossil-derived …

Development of a growth coupled and multi-layered dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin biosynthesis in Escherichia …

S Zhou, SF Yuan, PH Nair, HS Alper, Y Deng… - Metabolic …, 2021 - Elsevier
Metabolic heterogeneity and dynamic changes in metabolic fluxes are two inherent
characteristics of microbial fermentation that limit the precise control of metabolisms, often …

Multidimensional engineering of Saccharomyces cerevisiae for efficient synthesis of medium-chain fatty acids

Z Zhu, Y Hu, PG Teixeira, R Pereira, Y Chen… - Nature Catalysis, 2020 - nature.com
Medium-chain fatty acids (MCFAs; C6–C12) are valuable molecules used for biofuel and
oleochemical production; however, it is challenging to synthesize these fatty acids efficiently …

Update on food sources and biological activity of odd-chain, branched and cyclic fatty acids––A review

G Dąbrowski, I Konopka - Trends in Food Science & Technology, 2022 - Elsevier
Background Odd-, branched-chain and cyclic fatty acids are rare food components.
Recently, these compounds have generated great scientific interest, since they interact on …

Fatty acids derivatives from eukaryotic microalgae, pathways and potential applications

M Blasio, S Balzano - Frontiers in Microbiology, 2021 - frontiersin.org
The exploitation of petrochemical hydrocarbons is compromising ecosystem and human
health and biotechnological research is increasingly focusing on sustainable materials from …

Animal fatty acid synthase: a chemical nanofactory

P Paiva, FE Medina, M Viegas, P Ferreira… - Chemical …, 2021 - ACS Publications
Fatty acids are crucial molecules for most living beings, very well spread and conserved
across species. These molecules play a role in energy storage, cell membrane architecture …

Review of eukaryote cellular membrane lipid Composition, with special attention to the fatty acids

O Ali, A Szabó - International Journal of Molecular Sciences, 2023 - mdpi.com
Biological membranes, primarily composed of lipids, envelop each living cell. The intricate
composition and organization of membrane lipids, including the variety of fatty acids they …

Tracing insights into de novo lipogenesis in liver and adipose tissues

M Wallace, CM Metallo - Seminars in Cell & Developmental Biology, 2020 - Elsevier
Lipids play important roles in biology that include structural compartmentation as
membranes, energy storage, and regulatory functions as signaling molecules. These …

Engineering Yarrowia lipolytica to Produce Tailored Chain-Length Fatty Acids and Their Derivatives

K Wang, TQ Shi, L Lin, P Wei… - ACS synthetic …, 2022 - ACS Publications
Microbial production of value-added chemicals derived from fatty acids is a sustainable
alternative to petroleum-derived chemicals and unsustainable lipids from animals and …