As newer immunosuppressive regimens have steadily reduced the incidence of acute
rejection and have extended the life expectancy of allograft recipients, posttransplant …

Purpose This review assesses the current state of knowledge regarding preclinical and
clinical pharmacology for brain tumor chemotherapy and evaluates relevant brain tumor …

Objectives To assess the prevalence of and risk factors for urinary (UI) and fecal (FI)
incontinence in adults in long-term care (LTC) settings and in the community, the …

The choroid plexus (CP), ie, the blood–cerebrospinal fluid barrier (BCSFB) interface, is an
epithelial boundary exploitable for drug delivery to brain. Agents transported from blood to …

Leptomeningeal carcinomatosis (LMC) is a severe complication of cancers that markedly
shortens survival and lowers the quality of patients' life, and it still lacks adequate …

Among the various routes of drug administration, perhaps the least studied is
intracerebroventricular (ICV) administration. This route has been shown to be particularly …

Purpose Leptomeningeal disease (LMD) is an advanced metastatic disease presentation
portending a poor prognosis with minimal treatment options. The advent and widespread …

Primary central nervous system lymphomas (PCNSL) are aggressive malignancies that
arise in distinct anatomical sites, which display unique structural, biological and …

Neurologic dysfunction is a well-recognized adverse effect of cancer therapeutics. The most
common manifestations include peripheral neuropathy and encephalopathy. Often …

Purpose: The pharmacokinetics of intrathecally administered antibody or small-molecule
drugs in the human central nervous system (CNS) remains poorly understood. This study …