Serpins are a superfamily of proteins characterized by their common function as serine
protease inhibitors. So far, 36 serpins from nine clades have been identified. These proteins …

534 Hypertension September 2016 vasodilation is unrelated to the tissue kallikrein–kinin
system. 18 In addition, kallistatin transgenic mice were found to have significantly lower …

Diabetic retinopathy is a multifactorial disease, and the exact mechanism of its pathogenesis
remains obscure. Sirtuin 1 (Sirt1), a multifunctional deacetylase, is implicated in the …

Although Wnt signaling is known to mediate multiple biological and pathological processes,
its association with diabetic retinopathy (DR) has not been established. Here we show that …

The underlying molecular mechanism whereby hyperglycemia causes endothelial cell
apoptosis is not well understood. This study aims to elucidate the role of survival factor …

Pro-coagulant, anti-coagulant and fibrinolytic pathways are responsible for maintaining
hemostatic balance under physiological conditions. Any deviation from these pathways …

We previously reported that circulating levels of pigment epithelium-derived factor (PEDF), a
newly identified adipokine, are increased in patients with type 2 diabetes, correlating with …

OBJECTIVE Connective tissue growth factor (CTGF) is a major fibrogenic factor. Increased
retinal CTGF levels have been implicated to play a role in diabetic retinopathy. SERPINA3K …

Kallistatin is a serine proteinase inhibitor that has been shown to reduce joint swelling and
to inhibit inflammation in a rat model of arthritis. In this study, we investigated the effect and …

The Wnt pathway regulates multiple biological and pathological processes including
angiogenesis and inflammation. Here we identified a unique inhibitor of the Wnt pathway …