Voltage-gated potassium channels as therapeutic targets

H Wulff, NA Castle, LA Pardo - Nature reviews Drug discovery, 2009 - nature.com
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

The human obesity gene map: the 2005 update

T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel… - …, 2006 - Wiley Online Library
This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

[HTML][HTML] Mitochondrial channels: ion fluxes and more

I Szabo, M Zoratti - Physiological reviews, 2014 - journals.physiology.org
The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Olfaction under metabolic influences

B Palouzier-Paulignan, MC Lacroix, P Aimé… - Chemical …, 2012 - academic.oup.com
Recently published work and emerging research efforts have suggested that the olfactory
system is intimately linked with the endocrine systems that regulate or modify energy …

[HTML][HTML] The sense of smell impacts metabolic health and obesity

CE Riera, E Tsaousidou, J Halloran, P Follett, O Hahn… - Cell metabolism, 2017 - cell.com
Olfactory inputs help coordinate food appreciation and selection, but their role in systemic
physiology and energy balance is poorly understood. Here we demonstrate that mice upon …

Regulation of intestinal glucose absorption by ion channels and transporters

L Chen, B Tuo, H Dong - Nutrients, 2016 - mdpi.com
The absorption of glucose is electrogenic in the small intestinal epithelium. The major route
for the transport of dietary glucose from intestinal lumen into enterocytes is the Na+/glucose …

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

V Chi, MW Pennington, RS Norton, EJ Tarcha… - Toxicon, 2012 - Elsevier
Electrophysiological and pharmacological studies coupled with molecular identification
have revealed a unique network of ion channels—Kv1. 3, KCa3. 1, CRAC (Orai1+ Stim1) …

Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors

DR Marks, K Tucker, MA Cavallin, TG Mast… - Journal of …, 2009 - Soc Neuroscience
The role of insulin pathways in olfaction is of significant interest with the widespread
pathology of diabetes mellitus and its associated metabolic and neuronal comorbidities. The …

[HTML][HTML] Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction

L Bouchard, R Rabasa-Lhoret, M Faraj… - The American journal of …, 2010 - Elsevier
Background: Caloric restriction is recommended for the treatment of obesity, but it is
generally characterized by large interindividual variability in responses. The factors affecting …

The human obesity gene map: the 2004 update

L Pérusse, T Rankinen, A Zuberi, YC Chagnon… - Obesity …, 2005 - Wiley Online Library
This paper presents the eleventh update of the human obesity gene map, which
incorporates published results up to the end of October 2004. Evidence from single‐gene …