Exploiting urine-derived induced pluripotent stem cells for advancing precision medicine in cell therapy, disease modeling, and drug testing

X Yin, Q Li, Y Shu, H Wang, B Thomas… - Journal of Biomedical …, 2024 - Springer
The field of regenerative medicine has witnessed remarkable advancements with the
emergence of induced pluripotent stem cells (iPSCs) derived from a variety of sources …

Complex in vitro model: A transformative model in drug development and precision medicine

L Wang, D Hu, J Xu, J Hu… - Clinical and Translational …, 2024 - Wiley Online Library
In vitro and in vivo models play integral roles in preclinical drug research, evaluation, and
precision medicine. In vitro models primarily involve research platforms based on cultured …

Generation and characterization of cortical organoids from iPSC-derived dental pulp stem cells using traditional and innovative approaches

ALT e Silva, BY Yokota-Moreno, MS Branquinho… - Neurochemistry …, 2024 - Elsevier
Cortical organoids derived from human induced pluripotent stem cells (hiPSCs) represent a
powerful in vitro experimental system to investigate human brain development and disease …

The Potential of ChatGPT in Assisting Children with Down Syndrome

J Yang, LY Por, MC Leong, CS Ku - Annals of biomedical engineering, 2023 - Springer
ChatGPT, an advanced language generation model developed by OpenAI, has the potential
to revolutionize healthcare delivery and support for individuals with various conditions …

From neurodevelopment to neurodegeneration: Utilizing human stem cell models to gain insight into Down syndrome

LA Watson, HS Meharena - Frontiers in Genetics, 2023 - frontiersin.org
Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent
aneuploidy observed in the human population and represents the most common genetic …

Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

C Cavaleiro, GJM Afonso, PJ Oliveira… - Frontiers in Molecular …, 2023 - frontiersin.org
Stem cells have potential applications in the field of neurological diseases, as they allow for
the development of new biological models. These models can improve our understanding of …

[HTML][HTML] Application prospects of urine-derived stem cells in neurological and musculoskeletal diseases

HS Yang, YX Zheng, X Bai, XY He… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Urine-derived stem cells (USCs) are derived from urine and harbor the potential of
proliferation and multidirectional differentiation. Moreover, USCs could be reprogrammed …

[PDF][PDF] Realizing the potential of exploiting human IPSCs and their derivatives in research of Down syndrome

Y Wang, J Ni, Y Liu, D Liao, Q Zhou, X Ji, G Niu, Y Ni - Biocell, 2023 - cdn.techscience.cn
Down syndrome (DS) is a genetic condition characterized by intellectual disability, delayed
brain development, and early onset Alzheimer's disease. The use of primary neural cells …