Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases

G Wigerblad, MJ Kaplan - Nature Reviews Immunology, 2023 - nature.com
Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …

Neutrophil diversity in health and disease

C Silvestre-Roig, ZG Fridlender, M Glogauer… - Trends in …, 2019 - cell.com
New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

P Mistry, S Nakabo, L O'Neil, RR Goel… - Proceedings of the …, 2019 - National Acad Sciences
Neutrophil dysregulation is implicated in the pathogenesis of systemic lupus erythematosus
(SLE). SLE is characterized by elevated levels of a pathogenic neutrophil subset known as …

COVID‑19 and ischemic stroke: Mechanisms of hypercoagulability

S Zhang, J Zhang, C Wang… - International …, 2021 - spandidos-publications.com
During the coronavirus disease 2019 (COVID‑19) pandemic, some patients with severe
COVID‑19 exhibited complications such as acute ischemic stroke (AIS), which was closely …

Neutrophil extracellular traps induce intestinal damage and thrombotic tendency in inflammatory bowel disease

T Li, C Wang, Y Liu, B Li, W Zhang… - Journal of Crohn's …, 2020 - academic.oup.com
Abstract Background and Aims Despite the presence of neutrophil extracellular traps [NETs]
in inflamed colon having been confirmed, the role of NETs, especially the circulating NETs …

A bittersweet response to infection in diabetes; targeting neutrophils to modify inflammation and improve host immunity

R Dowey, A Iqbal, SR Heller, I Sabroe… - Frontiers in …, 2021 - frontiersin.org
Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D,
T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes …

Bite of the wolf: innate immune responses propagate autoimmunity in lupus

S Gupta, MJ Kaplan - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The etiopathogenesis of systemic lupus erythematosus (SLE), a clinically heterogeneous
multisystemic syndrome that derives its name from the initial characterization of facial …

NETosis and the immune system in COVID-19: mechanisms and potential treatments

C Gillot, J Favresse, F Mullier, T Lecompte… - Frontiers in …, 2021 - frontiersin.org
NETosis is a form of neutrophil death leading to the release of extracellular chromatin and
the assembling of proteins, including antiviral proteins, primed by an initial pathogenic …

Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases

I Aksentijevich, O Schnappauf - Nature Reviews Rheumatology, 2021 - nature.com
Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by
dysregulation in the innate immune system. The molecular mechanisms of these disorders …

Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease

R Grieshaber-Bouyer, PA Nigrovic - Frontiers in immunology, 2019 - frontiersin.org
Neutrophils are versatile innate effector cells essential for immune defense but also
responsible for pathologic inflammation. This dual role complicates therapeutic targeting …