Recent developments in bioprocessing of recombinant proteins: expression hosts and process development

NK Tripathi, A Shrivastava - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …

Economic analysis of batch and continuous biopharmaceutical antibody production: A review

O Yang, M Qadan, M Ierapetritou - Journal of pharmaceutical innovation, 2020 - Springer
Purpose There is a growing interest in continuous biopharmaceutical processing due to the
advantages of small footprint, increased productivity, consistent product quality, high …

Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies

L Gerstweiler, J Bi, APJ Middelberg - Chemical Engineering Science, 2021 - Elsevier
Continuous production delivers higher productivity and better quality than traditional batch-
wise approaches. It intensifies production lowering capital cost and enables better control …

Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals

S Nikita, A Tiwari, D Sonawat, H Kodamana… - Chemical Engineering …, 2021 - Elsevier
Process intensification in the form of continuous processing is presently being adopted by
the biopharmaceutical industry as it offers significant advantages over conventional …

Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?

AS Rathore, G Thakur, N Kateja - Biotechnology and …, 2023 - Wiley Online Library
Continuous integrated bioprocessing has elicited considerable interest from the biopharma
industry for the many purported benefits it promises. Today many major biopharma …

Challenges in process control for continuous processing for production of monoclonal antibody products

AS Rathore, S Nikita, G Thakur, N Deore - Current Opinion in Chemical …, 2021 - Elsevier
Continuous processing has been garnering much interest lately for production of
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …

Process analytical technology as key‐enabler for digital twins in continuous biomanufacturing

A Schmidt, H Helgers, LJ Lohmann… - Journal of Chemical …, 2022 - Wiley Online Library
Over the last few years rapid progress has been made in adopting well‐known process
modeling techniques from chemicals to biologics manufacturing. The main challenge has …

Economic assessment of continuous processing for manufacturing of biotherapeutics

P Gupta, N Kateja, S Mishra, H Kaur… - Biotechnology …, 2021 - Wiley Online Library
Continuous processing offers a promising approach to revolutionize biotherapeutics
manufacturing as reflected in recent years. The current study offers a comparative economic …

Biomimetic affinity chromatography for antibody purification: host cell protein binding and impurity removal

H Huang, X Dong, Y Sun, Q Shi - Journal of Chromatography A, 2023 - Elsevier
Peptide affinity chromatography has received increasing attention as an alternative to
protein A chromatography in antibody purification. However, its lower selectivity than protein …

[HTML][HTML] Purification of secretory IgA monoclonal antibodies enriched fraction directly from cell culture medium using aqueous two-phase systems

ACL Leite, TP Nascimento, MNC da Cunha… - International Journal of …, 2024 - Elsevier
Secretory immunoglobulin A [sIgA] is a promising candidate for enteric therapeutics
applications, and several sIgA-based constructs are currently being developed by groups …