Cholesterol and Alzheimer's disease; from risk genes to pathological effects

FM Feringa, R Van der Kant - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
While the central nervous system compromises 2% of our body weight, it harbors up to 25%
of the body's cholesterol. Cholesterol levels in the brain are tightly regulated for …

Cholesterol metabolism and homeostasis in the brain

J Zhang, Q Liu - Protein & cell, 2015 - academic.oup.com
Cholesterol is an essential component for neuronal physiology not only during development
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …

The role of the ATP-binding cassette A1 (ABCA1) in human disease

L Jacobo-Albavera, M Domínguez-Pérez… - International journal of …, 2021 - mdpi.com
Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Cellular cholesterol trafficking and compartmentalization

E Ikonen - Nature reviews Molecular cell biology, 2008 - nature.com
Cholesterol is an essential structural component in the cell membranes of most vertebrates.
The biophysical properties of cholesterol and the enzymology of cholesterol metabolism …

Cholesterol metabolism in neurons and astrocytes

FW Pfrieger, N Ungerer - Progress in lipid research, 2011 - Elsevier
Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

Role of brain liver X receptor in Parkinson's disease: hidden treasure and emerging opportunities

SA Alnaaim, HM Al-Kuraishy, A Alexiou… - Molecular …, 2024 - Springer
Parkinson's disease (PD) is a neurodegenerative disease due to the degeneration of
dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is …

Cholesterol: its regulation and role in central nervous system disorders

M Orth, S Bellosta - Cholesterol, 2012 - Wiley Online Library
Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …

[HTML][HTML] Cholesterol metabolism in the brain and its association with Parkinson's disease

U Jin, SJ Park, SM Park - Experimental neurobiology, 2019 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the
aging population after Alzheimer's disease (AD). Defects in the lysosomal systems and …

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

K Nieweg, H Schaller, FW Pfrieger - Journal of neurochemistry, 2009 - Wiley Online Library
Neurons have a high demand for cholesterol to develop and maintain membrane‐rich
structures like axons, dendrites and synapses, but it remains unclear, whether they can …

The cell biology of APOE in the brain

IA Windham, S Cohen - Trends in cell biology, 2024 - cell.com
Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE
is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other …