Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins

TNT Ho, N Abraham, RJ Lewis - Frontiers in Neuroscience, 2020 - frontiersin.org
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-
gated ion channels that mediate fast neurotransmission in the central and peripheral …

Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures

TH Al-Tel, V Srinivasulu, M Ramanathan… - Organic & …, 2020 - pubs.rsc.org
The last two decades or so have witnessed an upsurge in defining the art of designing
complex natural products and nature-inspired molecules. Throughout these decades …

Palladium/PC‐Phos‐Catalyzed Asymmetric Heck/Tsuji–Trost Reactions of Amino‐Tethered 1, 3‐Cyclohexadiene with Aryl and Alkenyl Halides

J Feng, J Shi, L Wei, M Liu, Z Li, Y Xiao… - Angewandte …, 2023 - Wiley Online Library
Chiral perhydroindoles are found in a number of natural products and biologically active
compounds. Therefore, the development of new asymmetric methodology for rapid access to …

Enantioselective Desymmetrization of para-Quinamines through an Aminocatalyzed Aza-Michael/Cyclization Cascade Reaction

L Pantaine, V Coeffard, X Moreau, C Greck - Organic letters, 2015 - ACS Publications
An unprecedented organocatalytic asymmetric desymmetrization of para-quinamines
leading to functionalized hydroindoles, a common motif in many alkaloids, has been …

The genus Erythrina L.: A review on its alkaloids, preclinical, and clinical studies

DF Rambo, R Biegelmeyer, NSB Toson… - Phytotherapy …, 2019 - Wiley Online Library
Erythrina L. genus (Fabaceae) comprises about 115 species, and it has been extensively
studied, mainly because of its alkaloids, which have pharmacological properties …

Synthesis of hydroindoles via desymmetric [3+ 2] cycloadditions of para-quinamines with photogenerated ketenes

D Liu, B Shi, H Jiang, Y Cheng, WJ Xiao… - Chemical …, 2021 - pubs.rsc.org
A DBU-catalyzed desymmetric [3+ 2] cycloaddition between para-quinamines and
photogenerated ketenes was developed for the first time. Under the irradiation of low-energy …

Divergent Synthesis of Aeruginosins Based on a C(sp3)H Activation Strategy

D Dailler, G Danoun, B Ourri… - Chemistry–A European …, 2015 - Wiley Online Library
A general and scalable access to the aeruginosin family of marine natural products,
exhibiting potent inhibitory activity against serine proteases, is reported. This was enabled …

Bioassay‐guided isolation of potent aphicidal Erythrina alkaloids against Aphis gossypii from the seed of Erythrina crista‐galli L

D Wang, N Xie, S Yi, C Liu, H Jiang, Z Ma… - Pest management …, 2018 - Wiley Online Library
BACKGROUND The cotton aphid (Aphis gossypii Glover) is one of the most invasive pests
of cotton. Many botanical phytochemicals have a long history as a source of insecticides …

Development of a divergent synthetic route to the erythrina alkaloids: asymmetric syntheses of 8‐oxo‐erythrinine, crystamidine, 8‐oxo‐erythraline, and erythraline

H Umihara, T Yoshino, J Shimokawa… - Angewandte …, 2016 - Wiley Online Library
A general synthetic methodology toward the erythrina alkaloids has been developed.
Inspired by a proposed biosynthetic mechanism, the medium‐sized chiral biaryl lactam was …

Silver‐Catalyzed [3+2] Cycloaddition for the Diastereoselective Synthesis of anti‐3‐Substituted Hydroindolin‐2‐Imines

Z Yang, X Luo, Z Zhang, X Luo, J Zheng… - Advanced Synthesis …, 2022 - Wiley Online Library
We describe a silver catalyzed [3+ 2] diastereoselective annulation of p‐quinamines and
ketenimine zwitterionic salts, leading to anti‐3‐substituted hydroindolin‐2‐imines under mild …