DNA2 nuclease/helicase is a structure-specific nuclease, 5′-to-3′ helicase, and DNA-
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …

Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This
family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator …

Background Identification of novel molecular target (s) is important for designing newer
mechanistically driven approaches for the treatment of prostate cancer (PCa), which is one …

Primary microcephalies (PMs) are defects in brain growth that are detectable at or before
birth and are responsible for neurodevelopmental disorders. Most are caused by biallelic or …

Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the
centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is …

Tumor immune microenvironment plays an important role in tumorigenesis and metastasis.
Polo-like kinases 4 (PLK4) is a crucial regulatory factor in the process of cell cycle, and its …

Primary microcephaly is a brain growth disorder characterized by a severe reduction of brain
size and thinning of the cerebral cortex. Many primary microcephaly mutations occur in …

Purpose: Uterine leiomyosarcoma (LMS) is an aggressive sarcoma and a subset of which
exhibits DNA repair defects. Polo-like kinase 4 (PLK4) precisely modulates mitosis, and its …

Maintenance of genome stability is a crucial cellular function for normal mammalian
development and physiology. However, despite the general relevance of this process …

Abstract Polo-like kinase 4 (PLK4) is a member of the serine/threonine protein kinase family
involved in cell-cycle regulation and cellular response to stresses. However, the alteration of …