Among the diseases causing human death, cardiovascular disease (CVD) remains number
one according to the World Health Organization report in 2021. It is known that …

In the wake of the Human Genome Project (HGP), strong expectations were set for the
timeline and impact of genomics on medicine—an anticipated transformation in the …

Cytosine base editors (CBEs) enable programmable genomic C· G-to-T· A transition
mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally occurring …

Importance Low-density lipoprotein cholesterol (LDL-C), a key cardiovascular disease
marker, is often estimated by the Friedewald or Martin equation, but calculating LDL-C is …

A main challenge to broaden the biomedical application of CRISPR/Cas9 (clustered
regularly interspaced short palindromic repeat (CRISPR) associated protein 9) genome …

Guidelines RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2
Diabetes Mellitus 2020Table. No title available.

Background Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin
type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular disease risk; …

The proprotein convertase subtilisin/kexin-type 9 (PCSK9) binds to low-density lipoprotein
receptors (LDLR), thereby trafficking them to lysosomes upon endocytosis and enhancing …

Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …

Foam cell formation and further accumulation in the subendothelial space of the vascular
wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the …