From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease which is
characterised by autoimmunity, widespread tissue fibrosis of the skin and internal organs …

Purpose: The success of immunotherapy for the treatment of metastatic cancer is contingent
on the identification of appropriate target antigens. Potential targets must be expressed on …

Autoimmune and inflammatory phenomena are characteristically present in systemic
sclerosis (SSc) and impact on dysregulated fibroblast extracellular matrix deposition …

Abstract Background Systemic sclerosis (SSc) is a multi-organ autoimmune disease
characterized by skin fibrosis. Internal organ involvement is heterogeneous. It is unknown …

Objective Fibrosis is a major contributor to morbidity and mortality in systemic sclerosis
(SSc). T cells are the predominant inflammatory infiltrate in affected tissue and are thought to …

Objective T lymphocytes play an important role in systemic sclerosis (SSc), a connective
tissue disease characterized by inflammation, fibrosis, and vascular damage. While their …

Abstract Interleukin-13 (IL-13) was previously thought to be a redundant presence of IL-4,
but in recent years its role in immunity, inflammation, fibrosis, and allergic diseases has …

Objective The aim of this paper is to review the anti-inflammatory cytokines IL-4 and IL-13
and their receptor signals; we discuss new insight into their possible roles in systemic …

Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to
induce activation responses which contribute to the inflammatory diseases. Genetic …