The liver has a critical role in regulating host metabolism, immunity, detoxification, and
homeostasis. Proper liver function is essential for host health, and dysregulation of hepatic …

WNT/β‐catenin signaling plays pivotal roles during liver development, homeostasis, and
regeneration. Likewise, its deregulation disturbs metabolic liver zonation and is responsible …

Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …

The roof plate-specific spondin–leucine-rich repeat-containing G-protein coupled receptor
4/5 (LGR4/5)–zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a …

Non-alcoholic fatty liver disease (NAFLD) is a liver disorder that has become a global health
concern due to its increasing prevalence. There is a need for reliable biomarkers to aid in …

Despite the high prevalence of alcoholic liver disease, its identification and characterization
remain poor, especially in early stages such as alcoholic fatty liver disease and alcoholic …

Abstract Background/Purpose Genome‐wide association studies have reported the
association of common variants with nonalcoholic fatty liver disease in genes, namely …

Triacylglycerol estolides (TG-EST) are biologically active lipids extensively studied for their
anti-inflammatory and anti-diabetic properties. In this work, eight standards of TG-EST were …

Background Wilson's disease (WD) results from pathogenic ATP7B gene variations, causing
copper accumulation mainly in the liver, brain, and kidneys. Objectives In India, despite …

The 3Rs principles—reduction, refinement, replacement—are at the core of preclinical
research within drug discovery, which still relies to a great extent on the availability of …