Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …

Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2)
increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD) …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

In the present report, we extend previous findings in the 5XFAD mouse model and
demonstrate that these mice develop an age-dependent motor phenotype in addition to …

Background Although the mechanism of neuron loss in Alzheimer's disease (AD) is
enigmatic, it is associated with cerebral accumulation of Aβ 42. The 5XFAD mouse model of …

Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …

The cholinergic hypothesis of cognitive impairment and Alzheimer's disease has been for
decades a “polar star” for studies on dementia and neurodegenerative diseases. Aim of the …