The “integrin” terminology was applied in a 1987 review article (1) to describe a family of
structurally, immunochemically, and functionally related cell-surface heterodimeric …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

Bone-marrow minimal residual disease (MRD) causes relapse after chemotherapy in
patients with acute myelogenous leukemia (AML). We postulate that the drug resistance is …

This review focuses on providing insights into the structural basis and clinical relevance of
LFA‐1 and VLA‐4 inhibition by peptides and small molecules as adhesion‐based …

Introduction 3. Discussion 3.1. Fibronectin 3.2. Integrins 3.3. Molecular mechanisms of
ligand-integrin interactions 3.4. Ligand specificity of fibronectin binding integrins 3.5 …

The N-terminal≈ 440 aa of integrin α subunits contain seven sequence repeats. These are
predicted here to fold into a β-propeller domain. A homologous domain from the enzyme …

Because monoclonal antibodies (mAbs) directed against alpha4-integrin and VCAM-1
inhibit the development of experimental autoimmune encephalomyelitis (EAE) in vivo, it has …

MDC-15 (ADAM-15, metargidin), a membrane-anchored metalloprotease/disintegrin/
cysteine-rich protein, is expressed on the surface of a wide range of cells and has an RGD …

Background Sublingual immunotherapy (SLIT) for grass pollen allergy can modify the
natural history of allergic rhinitis and is associated with increased allergen‐specific IgG4 …

Integrins are αβ heterodimeric cell-surface receptors that are vital to the survival and function
of nucleated cells. They recognize aspartic-acid-or a glutamic-acid-based sequence motifs …