Venn diagrams are widely used tools for graphical depiction of the unions, intersections and
distinctions among multiple datasets, and a large number of programs have been developed …

Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a
variety of biological functions. Here we discuss the emerging archetypes of molecular …

Although both homologous recombination (HR) and nonhomologous end joining can repair
DNA double-strand breaks (DSBs), the mechanisms by which one of these pathways is …

Parental epigenomes are established during gametogenesis. While they are largely reset
after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated …

Histones function both positively and negatively in the regulation of gene expression, mainly
governed by post-translational modifications on specific amino acid residues. Although …

Germ cell development creates totipotency through genetic as well as epigenetic regulation
of the genome function. Primordial germ cells (PGCs) are the first germ cell population …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant,
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …

The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2
are recruited to target sites in vertebrate cells are not well understood. Building on recent …

The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at
mammalian heterochromatin. We show here that the mouse Suv39h2 enzyme differs from …