Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

Sarcoidosis is a systemic disease of unknown etiology defined by the presence of
noncaseating granulomatous inflammation that can cause organ damage and diminished …

Uveitis is the most common form of intraocular inflammatory disease and is a significant
cause of visual impairment worldwide. Aetiologically, uveitis can also be classified into …

Objective More than 80% of autoimmune disease predominantly affects females, but the
mechanism for this female bias is poorly understood. We suspected that an X chromosome …

Sarcoidosis is a multisystem disease with tremendous heterogeneity in disease
manifestations, severity, and clinical course that varies among different ethnic and racial …

Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …

Sarcoidosis is a complex disease that belongs to the vast group of autoinflammatory
disorders, but the etiological mechanisms of which are not known. At the crosstalk of …

Uveitis is a generic term for inflammation of the uvea, which includes the iris, ciliary body,
and choroid. Prevalence of underlying non-infectious uveitis varies by race and region and …

Sarcoidosis is a multisystem granulomatous disease that may affect any body organ.
Sarcoidosis is associated with many environmental and occupational exposures. Because …

Rationale: Genetic variation plays a significant role in the etiology of sarcoidosis. However,
only a small fraction of its heritability has been explained so far. Objectives: To define further …