Parkinson disease (PD) is the second-most common neurodegenerative disease. The
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …

Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the
aging population after Alzheimer's disease (AD). Defects in the lysosomal systems and …

Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …

Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid
peroxidation. Recent research has identified many regulators that induce or inhibit …

Altered levels of sphingolipids and their metabolites in the brain, and the related
downstream effects on neuronal homeostasis and the immune system, provide a framework …

Brain injuries and neurological diseases have a significant impact on the gut microbiome
and the gut barrier. Reciprocally, gut disorders, such as Inflammatory Bowel Syndromes …

Abstract Phospholipid Transfer Protein (PLTP) transfers amphiphilic lipids between
circulating lipoproteins and between lipoproteins, cells and tissues. Indeed, PLTP is a major …

The blood-brain barrier (BBB) is a selective, semi-permeable layer of endothelial cells that
protects the central nervous system from harmful substances circulating in blood. It is one of …

Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized
by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence …

Abstract TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein that regulates
gene expression, and its malfunction in neurons has been causally associated with multiple …