Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …

The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …

Several clinical studies reported an increased prevalence and accelerated progression of
aortic valve calcification among patients with end-stage renal disease when compared with …

Cardiovascular diseases remain the primary cause of death. 1 Myocardial infarction (MI),
angina, and stroke take> 16 million lives every year, but the underlying mechanisms by …

Despite the elucidation of the pathways behind the development of aortic stenosis (AS),
there remains no effective medical treatment to slow or reverse its progress. Instead, the …

Surgical replacement of dysfunctional valves is the primary option for the treatment of
valvular disease and congenital defects. Existing mechanical and bioprosthetic replacement …

Cardiovascular disease (CVD) is an important cause of death in patients with chronic kidney
disease (CKD), and cardiovascular calcification (CVC) is one of the strongest predictors of …

Valvular heart calcification is common in patients with chronic kidney disease (CKD),
especially in those receiving hemodialysis therapy, and it is associated with poor prognosis …

In patients with aortic stenosis (AS), a novel staging classification of extra-valvular left and
right heart damage with prognostic relevance was introduced in 2017. The aim of the study …

Aortic valve stenosis (AS) is the most common form of valvular heart disease in the Western
world, affecting~ 40% of the population over the age of 80; to date the only established …