The Mre11–Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair
of DNA double-strand breaks and other DNA termini in all kingdoms of life. It is an intricate …

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …

DNA double-strand breaks (DSBs) are a significant threat to cell viability due to the induction
of genome instability and the potential loss of genetic information. One of the key players for …

Abstract 3C-based methods have significantly advanced our understanding of 3D genome
organization. However, it remains a formidable task to precisely capture long-range …

Some transcription factors (TFs) can form liquid–liquid phase separated (LLPS)
condensates. However, the functions of these TF condensates in 3-Dimentional (3D) …

Objective Evidence suggests that calcium release from the endoplasmic reticulum (ER) can
be induced to cause calcium overload, which in turn can trigger mitochondrial-dependent …

Heterochromatin is a conserved feature of eukaryotic chromosomes, with central roles in
gene expression regulation and maintenance of genome stability. How heterochromatin …

Some transcription factors (TFs) can form liquid-liquid phase separated (LLPS)
condensates. However, the functions of these TF condensates in 3D genome organization …

DNA double-strand breaks (DSBs) are one of the most frequent causes of initiating
cancerous malformations, therefore, to reduce the risk, cells have developed sophisticated …

Beyond their canonical function in nucleocytoplasmic exchanges, nuclear pore complexes
(NPCs) regulate the expression of protein-coding genes. Here, we have implemented …