Pharmacogenomic testing can be an effective tool to enhance medication safety and
efficacy. Pharmacogenomically actionable medications are widely used, and approximately …

Polymorphisms of genes encoding drug metabolizing enzymes and transporters can
significantly modify pharmacokinetics, and this can be associated with significant differences …

Traditionally, clinical pharmacology has focused its activities on drug-organism interaction,
from an individual or collective perspective. Drug efficacy assessment by performing …

The treatment of depression represents a major challenge for healthcare systems and
choosing among the many available drugs without objective guidance criteria is an error …

Pharmacogenomic testing may be used to improve treatment outcomes and reduce the
frequency of adverse drug reactions (ADRs). Population specific, targeted …

Pharmacogenetic (PGx) literature has shown beneficial outcomes in safety, efficacy and cost
when evidence-based gene-drug decision making is incorporated into clinical practice. PGx …

Importance Nonadherence to statin guidelines is common. The solute carrier organic anion
transporter family member 1B1 (SLCO1B1) genotype is associated with simvastatin …

The paradigm “one drug fits all” or “one dose fits all” will soon be challenged by
pharmacogenetics research and application. Drug response—efficacy or safety—depends …

The development of Pharmacogenetics and Pharmacogenomics in Western Europe is
highly relevant in the worldwide scenario. Despite the usually low institutional support, many …

Over the last two decades, pharmacogenetics and pharmacokinetics have been increasingly
used in clinical practice in Psychiatry due to the high variability regarding response and side …