Organoids are multicellular structures that can be derived from adult organs or pluripotent
stem cells. Early versions of organoids range from simple epithelial structures to complex …

Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …

Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …

Brain organoids created from human pluripotent stem cells represent a promising approach
for brain repair. They acquire many structural features of the brain and raise the possibility of …

Modeling the processes of neuronal progenitor proliferation and differentiation to produce
mature cortical neuron subtypes is essential for the study of human brain development and …

The biology of the human brain, and in particular the dynamic interactions between the
numerous cell types and regions of the central nervous system, has been difficult to study …

Recent advances in 3D cell culture technology have enabled scientists to generate stem cell
derived organoids that recapitulate the structural and functional characteristics of native …

As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Abstract Parkinson's disease (PD), a neurodegenerative disease that shows a high
incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there is no …

Organoids derived from human pluripotent stem cells are interesting models to study
mechanisms of morphogenesis and promising platforms for disease modeling and drug …